空白行

Academic Activity

【受 賞】

2002年度日本人工臓器学会 JSAO-Grant
eNOS遺伝子導入骨髄細胞により被覆されたハイブリッド人工血管の開存性に関する実験的検討 第 40回日本人工臓器学会総会(2002/10札幌)

【学会発表(国際学会)】

1)Heparin coated cardiopulmonary bypass circuit in coronary bypass surgery. The Third World Artificial Organ, Immunology and Transplantation Symposium (1995/07 Sapporo)

2)Hepatocyte xenotransplantation for Nagase’s analubuminemic rats; Effect of FK506. The Third International Congress For Xenotransplantation (1995/09 Boston)

3)The effect of blocking of selectin-dependent intercellular signals on graft survival in rat cardiac allotransplantation. The 16th Annual Meeting of International Society For Heart and Lung Transplantation (1996/03 New York)
4)Significant prolongation of garft survival by blocking intercellular signals via adhesion molecules in rat cardiac allografts Third Congress of the International Society for Experimental Microsurgery (1996/09 Wuerzburg)
5)Immunoregulation via adhesion molecules in allogenic or xenogenic hepatocyte transplantation in Nagase’s analbuminemic rats. Third International Congress of The Cell Transplant Society (1996/09 Miami)
6)Transplantation tolerance to rat cardiac allografts by a combination treatment of sulfatide, anti-adhesion molecule antibodies and FK506. The 8th Congress of The European Society For Organ Transplantation (1997/09 Budapest)
7)The L-arginine-nitric oxide pathway is involved in the preconditioning response of rabbit hearts treated with nicorandil. The 70th Scientific Sessions of The American Heart Association (1997/11 Orlando)
8)Nitric oxide is a requisite cofactor to generate ATP-sensitive potassium channel-mediated preconditioning. The 84th Annual Clinical Congress of American College of Surgeons -Surgical Forum- (1998/10 Orlando)
9)The L-arginine-nitric oxide generated preconditioning response is mediated through a cGMP-dependent mechanism. The 71st Scientific Sessions of The American Heart Association (1998/11 Atlanta)
10)Nitric oxide generating beta adrenergic blocker nipradilol preserves post ischemic cardiac function. The 35th Annual Meeting of The Society of Thoracic Surgeons (1999/01 San Antonio)
11)L-arginine preconditioned the heart through nitric oxide generation. The 7th Annual Meeting of the Asian Society For Cardiovascular Surgery (1999/05 Singapore)
12)The nitric oxide generating beta-adrenergic blocker nipradilol preconditions the heart through a NO-cyclic GMP-dependent mechanism. The 72nd Scientific Sessions of The American Heart Association (1999/11 Dallas)
13)Pancreas-selective ATP-sensitive potassium channel blocker glimepiride does not affect myoprotective effects of ischemic preconditioning in rabbits . The 49th International Congress of The European Society for Cardiovascular Surgery ( 2000/06 Dresden)
14) HMG-CoA reductase inhibitor cerivastatin prolonged rat cardiac allograft survival by blocking intercellular signals. The 21st Annual Meeting of International Society for Heart and Lung Transplantation (2001/4 Vancouver)
【著 書】

Horimoto H , Kondo K, Asada K, Sasaki S. Heparin-coated cardiopulmonary bypass circuits in coronary bypass surgery. Immunomodulation in immune disorders and organ substitution. Blackwell Science, Inc. 1998, 116-120.

【原著論文(英文)】

1)Horimoto H , Kokudo N, Otsu I, Nozawa M. Hepatocyte xenotransplantation for Nagase’s analbuminemic rats: the effect of FK506.Transplant Proc. 1996, 28:829-30.
2)Horimoto H , Kondo K, Asada K, Sasaki S. Heparin-coated cardiopulmonary bypass circuits in coronary bypass surgery. Artif Organs. 1996, 20:936-40.
3)Kokudo N, Horimoto H , Ishida K, Takahashi S, Nozawa M. Allogeneic hepatocyte and fetal liver transplantation and xenogeneic hepatocyte transplantation for Nagase’s analbuminemic rats. Cell Transplant. 1996, 5:S21-2.
4)Horimoto H , Nozawa M, Kokudo N, Nakao M, Takahashi S, Miyasaka M, Seino K, Yagita H, Okumura K. Immunoregulation via adhesion molecules in allogenic and xenogenic hepatocyte transplantation to Nagase’s analbuminemic rats.Cell Transplant. 1997,6:535-6.
5)Horimoto H , Ito T, Hayashi T, Miyasaka M, Nozawa M. Transplantation tolerance by a combined therapy with sulfatide, anti-LFA-1/ICAM-1 monoclonal antibodies and FK506 in rat cardiac transplantation. Transpl Int. 1998;11:S310-2.
6)Horimoto H , Saltman AE, Gaudette GR, Krukenkamp IB. Nitric oxide-generating beta-adrenergic blocker nipradilol preserves postischemic cardiac function. Ann Thorac Surg. 1999, 68:844-9
7)Horimoto H , Gaudette GR, Saltman AE, Krukenkamp IB. The role of nitric oxide, K(+)(ATP) channels, and cGMP in the preconditioning response of the rabbit. J Surg Res. 2000, 92:56-63.
8)Saltman AE, Krukenkamp IB, Gaudette GR, Horimoto H , Levitsky S. Pharmacological preconditioning with the adenosine triphosphate-sensitive potassium channel opener pinacidil. Ann Thorac Surg. 2000, 70:595-601.
9)Gaudette GR, Krukenkamp IB, Saltman AE, Horimoto H , Levitsky S. Preconditioning with PKC and the ATP-sensitive potassium channels: a codependent relationship. Ann Thorac Surg. 2000,70:602-8.
10)Suematsu Y, Ohtsuka T, Horimoto H , Maeda K, Nakai Y, Mieno S, Takamoto S. Long-term treatment with nipradilol, a nitric oxide-releasing beta-adrenergic blocker, enhances postischemic recovery and limits infarct size. Ann Thorac Surg. 2002;73:173-9.
11)Horimoto H , Nakai Y, Nakahara K, Nomura Y, Mieno S, Sasaki S. HMG-CoA reductase inhibitor cerivastatin prolonged rat cardiac allograft survival by blocking intercellular signals. J Heart Lung Transplant. 2002; 21:440-5.
12)Nakai Y, Horimoto H , Mieno S, Sasaki S. Na(+)/H(+) exchanger inhibitor HOE642 offers myoprotection in senescent myocardium independent of ischemic preconditioning mechanisms. Eur Surg Res. 2002;34:244-50.
13)Horimoto H , Nakai Y, Mieno S, Nomura Y, Nakahara K, Sasaki S. Oral hypoglycemic sulfonylurea glimepiride preserves the myoprotective effects of ischemic preconditioning. J Surg Res. 2002;105:181-8.
14)Okuda N, Hayashi T, Mori T, Inamoto S, Okabe M, Mieno S, Horimoto H , Kitaura Y. Nifedipine enhances the cardioprotective effect of an angiotensin-II receptor blocker in an experimental animal model of heart failure. Hypertens Res. 2005; 28:431-8.
15)Kanki-Horimoto S, Horimoto H , Mieno S, Kishida K, Watanabe F, Furuya E, Katsumata T. Synthetic vascular prosthesis impregnated with genetically modified bone marrow cells produced recombinant proteins. Artif Organs. 2005; 29:815-9.
16)Mieno S, Horimoto H , Sawa Y, Watanabe F, Furuya E, Horimoto S, Kishida K, Sasaki S. Activation of beta2-adrenergic receptor plays a pivotal role in generating the protective effect of ischemic preconditioning in rat hearts. Scand Cardiovasc J. 2005; 39:313-9.
17)Mieno S, Horimoto H , Kishida K, Horimoto S, Sasaki S. Landiolol enhances effect of ischemic preconditioning in isolated rabbit hearts. Asian Cardiovasc Thorac Ann. 2006; 14:239-43.
18)Kanki-Horimoto S, Horimoto H , Mieno S, Kishida K, Watanabe F, Furuya E, Katsumata T. Implantation of mesenchymal stem cells overexpressing endothelial nitric oxide synthase improves right ventricular impairments caused by pulmonary hypertension. Circulation. 2006; 114(1 Suppl):I181-5.

19)Kanki-Horimoto S, Horimoto H , Mieno S, Kishida K, Watanabe F, Furuya E, Katsumata T. Synthetic vascular prosthesis impregnated with mesenchymal stem cells overexpressing endothelial nitric oxide synthase. Circulation. 2006 Jul 4; 114(1 Suppl):I327-30.

【学位指導論文】

1)Nakai Y, Horimoto H , Mieno S, Sasaki S. Mitochondrial ATP-sensitive potassium channel plays a dominant role in ischemic preconditioning of rabbit heart. Eur Surg Res. 2001;33:57-63.
2)Mieno S, Horimoto H , Watanabe F, Nakai Y, Furuya E, Sasaki S. Potent adenylate cyclase agonist forskolin restores myoprotective effects of ischemic preconditioning in rat hearts after myocardial infarction. Ann Thorac Surg. 2002 ;74:1213-8.
3)Yoshida M, Horimoto H , Mieno S, Nomura Y, Okawa H, Nakahara K, Sasaki S. Intra-arterial bone marrow cell transplantation induces angiogenesis in rat hindlimb ischemia. Eur Surg Res. 2003;35:86-91.
4)Nakahara K, Horimoto H , Nakai Y, Mieno S, Nomura Y, Sasaki S. Left ventricular mechanical unloading restores Beta-2-adrenergic receptor mRNA expression and decreases susceptibility to ischemia and reperfusion in the failing heart. Eur Surg Res. 2003 ;35:108-14.
5)Okawa H, Horimoto H , Mieno S, Nomura Y, Yoshida M, Shinjiro S. Preischemic infusion of alpha-human atrial natriuretic peptide elicits myoprotective effects against ischemia reperfusion in isolated rat hearts. Mol Cell Biochem. 2003; 248:171-7.
6)Nomura Y, Horimoto H , Mieno S, Nakahara K, Okawa H, Yoshida M, Shinjiro S. Repetitive preischemic infusion of phosphodiesterase III inhibitor olprinone elicits cardioprotective effects in the failing heart after myocardial infarction. Mol Cell Biochem. 2003; 248:179-84.
7)Kanki-Horimoto S, Horimoto H , Mieno S, Kishida K, Watanabe F, Furuya E, Katsumata T. Synthetic vascular prosthesis impregnated with genetically modified bone marrow cells produced recombinant proteins. Artif Organs. 2005; 29:815-9.